HOME >> Spray dry manufacturing technology
In the building dedicated to spray dry manufacturing, 2 spray driers for manufacturing scale production are installed, where technology of achieving a drug-delivery system with drug/drug inclusion complexes and technology of making slightly soluble medicines soluble are applied for manufacturing scale production. In April 2007, a spray drier for pilot plant scale production was newly installed. Manufacture of investigational products and manufacture of drug products in small lots is also practicable.
| Process | Name of facility or equipment | Manufacturer & model | Capacity & specifications | |
| Liquid preparation | For manufacturing scale production | Dispersion tank | Daiwa Kakoki | 1300 L tank |
| Storage tank | Daiwa Kakoki | 1300 L tank | ||
| Solution preparation tank | Ohkawara Kakohki Co., Ltd. | 200 L tank x 2 tanks | ||
| For pilot plant scale production | Solution preparation tank | KI Kakoki Co., Ltd. | 500 L tank | |
| Feeding tank | KI Kakoki Co., Ltd. | 250 L tank | ||
| Service tank | - | 50 L | ||
| SD washing water pump | Nikunima-shinari 641-1S | 70 L/min | ||
| SD pump | Heishin Ltd. | 60 kg/h x 2 pumps | ||
| Continuous vacuum degasser | Ebara Corporation UDC1-SM | 60 L/h | ||
| Spray dry | For manufacturing scale production | Spray drier | Ohkawara Kakohki Co., Ltd. Model CS-50 | Drum body diameter: 2.75 m Height: 3 m for straight tube portion, 2.5 m for cone portion Amount of moisture evaporation: 55.5 kg/h Disk spray-parallel method Water soluble solvents only |
| Ohkawara Kakohki Co., Ltd. Model ODA-27 | ||||
| For pilot plant scale production | Spray drier | Ohkawara Kakohki Co., Ltd. Model OC-20 | Drum body diameter: 2 m Height: 1.2 m for straight tube portion, 1.7 m for cone portion Amount of moisture evaporation: 23 -42 kg/h Disk spray-parallel method Water soluble solvents only |
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| Facility for water for manufacturing | RO membrane-ion exchange unit | NGK Filtech, Ltd. | 1.0 m3/h | |
| Mixing & subdividing | Bohle container mixer | Kotobuki Industries Co., Ltd. MC1200/PM1000 | 1200 L tank x 3 tanks | |
| Circular oscillating sieve | Tokuju Corporation TM-50 | Output: 0.4 KW | ||
| Metallic foreign bodies eliminating apparatus | Magnetec Japan Ltd. | Grid type magnet 12000 gauss x 14 units | ||
| Automatic can weighing apparatus | Osaka Godo Keiso | 30 kg at maximum x 2 units | ||
